Prevention of nut allergies in high risk infants

Research Opportunity
PhD students
Department / Centre
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
A/Prof Kirsten Perrett kirsten.perrett@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Vicki McWilliam vicki.mcwilliam@mcri.edu.au

Summary Peanut allergy affects around 3% of children and around a third of those will go on to develop further nut (tree nut) allergies. Early introduction of peanut and egg into the diet has been found to be protective for the development of peanut and egg allergies and as such introduction before 12 months of age is now part of many international infant feeding guidelines. We have observational data that suggests timely introduction of tree nuts may also be protective and avoidance detrimental for the development of tree nut allergy. TreEAT (n=212) is a randomised controlled trial testing a new model of care for the prevention of tree nut allergies in infants at high risk. Infants with newly diagnosed peanut allergy are randomised to receive an in hospital supervised multi-nut (4 tree nut butter) food challenge or standard care (individual cautious tree nut introduction at home). This is a world-first trial of an intervention for the secondary prevention of tree nut allergies. The findings will have immediate translational importance and inform allergy prevention guidelines globally.

Project Details

Peanut allergy affects around 3% of children and around a third of those will go on to develop further nut (tree nut) allergies. Early introduction of peanut and egg into the diet has been found to be protective for the development of peanut and egg allergies and as such introduction before 12 months of age is now part of many international infant feeding guidelines. We have observational data that suggests timely introduction of tree nuts may also be protective and avoidance detrimental for the development of tree nut allergy. TreEAT (n=212) is a randomised controlled trial testing a new model of care for the prevention of tree nut allergies in infants at high risk. Infants with newly diagnosed peanut allergy are randomised to receive an in hospital supervised multi-nut (4 tree nut butter) food challenge or standard care (individual cautious tree nut introduction at home). This is a world-first trial of an intervention for the secondary prevention of tree nut allergies. The findings will have immediate translational importance and inform allergy prevention guidelines globally.       

 

We are looking for an enthusiastic PhD candidate to join our friendly, dynamic multidisciplinary TreEAT trial team including clinician and research scientists, and epidemiologists. The candidate will have the opportunity to be involved in hands-on clinical trial research participating in the assessment of participants and will analyse the detailed questionnaire, quality of life, healthcare and clinical allergy data from enrolment (<11 months of age) and follow-up (at 18 months). This project would suit a clinician (e.g. paediatrician, dietitian, allergist) or a scientist with an interest and some content knowledge in these areas. Excellent people skills are essential, and some experience of data management and statistical analysis would be beneficial.   



Faculty Research Themes

School Research Themes



Research Opportunities

PhD students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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