Pregnancy Specific beta-1 glycoproteins (PSGs) and their role and function in preeclampsia and fetal growth restriction
- Research Opportunity
- Number of Honour Places Available
- Obstetrics and Gynaecology
- Austin Health
|Associate Professor Tu'uhevaha Kaitu'u-Linofirstname.lastname@example.org||8458 4355||Personal web page|
Summary PSGs 4, 7 and 9 are highly expressed in placenta and may have important roles in diseases of pregnancy including preeclampsia and fetal growth restriction. The aim of this project will be to characterise the expression of these molecules in placental and blood samples already collected from women with these diseases. In addition, functional studies to elucidate the regulation of these molecules will be undertaken using primary human placental cells and tissues.
Preeclampsia and Fetal Growth Restriction are serious complications of pregnancy and are leading causes of maternal and fetal morbidity and mortality. This project will focus on placental specific beta-glycoproteins that are highly expressed in the placenta and may contribute to the pathogenesis of these diseases. We will use placental samples obtained from women delivering at the Mercy Hospital for Women and undertake functional studies to determine the potential contribution of these molecules to disease. The project will be undertaken at the Mercy Hospital for Women in Heidelberg within the Department of Obstetrics and Gynaecology.
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