Pregnancy Specific beta-1 glycoproteins (PSGs) and their role and function in preeclampsia and fetal growth restriction

Research Opportunity
Honours
Number of Honour Places Available
1
Department
Obstetrics and Gynaecology
Location
Austin Health
Primary Supervisor Email Number Webpage
Associate Professor Tu'uhevaha Kaitu'u-Lino t.klino@unimelb.edu.au 8458 4355 Personal web page

Summary PSGs 4, 7 and 9 are highly expressed in placenta and may have important roles in diseases of pregnancy including preeclampsia and fetal growth restriction. The aim of this project will be to characterise the expression of these molecules in placental and blood samples already collected from women with these diseases. In addition, functional studies to elucidate the regulation of these molecules will be undertaken using primary human placental cells and tissues.

Project Details

Preeclampsia and Fetal Growth Restriction are serious complications of pregnancy and are leading causes of maternal and fetal morbidity and mortality.  This project will focus on placental specific beta-glycoproteins that are highly expressed in the placenta and may contribute to the pathogenesis of these diseases. We will use placental samples obtained from women delivering at the Mercy Hospital for Women and undertake functional studies to determine the potential contribution of these molecules to disease. The project will be undertaken at the Mercy Hospital for Women in Heidelberg within the Department of Obstetrics and Gynaecology.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine, Women's Health



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Obstetrics and Gynaecology

Research Node

Austin Health

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