Predictors and mechanisms of cutaneous adverse drug reactions: a multi-omic approach

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
Medicine and Radiology
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Professor Patrick Kwan
Co-supervisor Email Number Webpage
Dr Alison Anderson

Project Details

Mainstream anti-epileptic drugs (AEDs) that are used to treat epilepsy and some other conditions are associated with a range of cutaneous side effects. Genetic analyses that compare the genomes of those who develop an adverse reaction with those that are tolerant to AEDs has identified specific genetic markers that increase susceptibility in some but not all individuals. It is increasingly understood that multiple genomic and /or environmental factors contribute to drug sensitivity. A better understanding of the underlying molecular mechanisms will enhance capacity for personalised treatment and the design of safer drugs. This project represents a unique opportunity to investigate the underlying molecular mechanisms by integrating genomic analysis with transcriptomics (gene expression) approaches. The transcriptome, derived from T-cells, will be used to identify genes that are differentially expressed or that change their pattern of co-expression in cells from drug-exposed cases as compared to those from drug-tolerant controls. The student will be part of a multidisciplinary team with expertise in neurology, cell biology and bioinformatics and gain an understanding of the rapidly evolving field of pharmacogenomics.

Faculty Research Themes


School Research Themes

Neuroscience & Psychiatry

Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Node

Royal Melbourne Hospital

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