POPS (proactive care of older people undergoing surgery)

Research Opportunity
Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Prof Kwang Lim Kwang.Lim@mh.org.au
Co-supervisor Email Number Webpage
Dr Rachel Aitken rachel.aitken@mh.org.au
Dr Katherine Gregorevic Katherine.Gregorevic@mh.org.au

Summary The Proactive Care of Older people undergoing Surgery is a new service that has been started at RMH. It aims to assess and evaluate older people undergoing elective surgery by performing a comprehensive assessment preoperatively, including the use of frailty scales and functional assessments.

Project Details

The world is experiencing an alarming rise in the incidence of cardiovascular disease, obesity and poor metabolic health. Mounting evidence suggests Adverse post-operative outcomes and prolonged hospital length of stay (LOS) are more common in older than in younger people following surgery. One-fifth of patients aged 70+ undergoing non-cardiac surgery will develop one or more serious post-operative complications. However symptom and pain control, functional status and quality of life is commonly improved in older people following elective surgery. By addressing modifiable risk factors before surgery we aim to reduce post operative complications and improve outcomes in older people undergoing surgery.

The Proactive Care of Older people undergoing Surgery is a new service that has been started at RMH. It aims to assess and evaluate older people undergoing elective surgery by performing a comprehensive assessment preoperatively, including the use of frailty scales and functional assessments.

Objective: to evaluate an evidence-based comprehensive geriatric assessment (CGA) service for at-risk older patients undergoing elective orthopaedic and vascular surgery.

Setting: Royal Melbourne Hospital

Subjects: elective surgical patients aged 65+.

Intervention: multidisciplinary preoperative CGA service with post-operative follow-through (proactive care of older people undergoing surgery [‘POPS’]).

Methods: observational cohort study). Prospective ‘before and after’ comparison (exploratory evaluation)

The period in utero and early postnatally plays a critical role in programming these phenotypes. Both genetic and environmental factors contribute to complex disease risk and are also known to influence epigenetic profile. Thus, epigenetic variation has emerged as prime candidate for the early life programming of later CV and metabolic health.  Epigenetic variants have great potential as biomarkers for monitoring ideas progression and may be reversible with appropriate intervention. The overall aims of this project are to examine the association of epigenetic variation in early life (with a focus on DNA methylation), genetic variation and environmental exposures, with measures of adiposity and cardiovascular health in the unique Barwon Infant study of 1000 mothers and their children (www.barwoninfantstudy.org.au/). BIS has a wealth of environmental measures and longitudinally sampled biospecimens with genome-wide genetic data already collected, enabling an unprecedented investigation of the role of genes, environment and epigenetics in conferring early life risk of cardio/metabolic health in humans.


School Research Themes

Ageing, Cardiometabolic



Research Opportunities

Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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