Personalised Clinical Trials in Psychiatry

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Psychiatry
Supervisor Email Number Webpage
Bernhard Baune bbaune@unimelb.edu.au

Project Details

Honours and PhD students can be actively involved in the below original clinical trials to recruit participants, to analyse data and to generate biological data in the lab, if if interest. Publication of results is encouraged and support and training is provided.

Ketamine Adult Depression Study 

The Ketamine for Adult Depression Study (KADS) is a multi-centre trial across Australia and New Zealand, investigating the use of ketamine for treatment resistant depression. The KADS Adelaide site is run by the Department of Psychiatry, with Professor Bernhard Baune as the Principal Investigator.

Ketamine is a medication used for anaesthesia, sedation and pain relief. However in this study, ketamine is given in much lower doses than those used for anaesthesia. Low dose ketamine has been found to reduce symptoms of depression rapidly and effectively, but the use of ketamine in treating depression is still under investigation.

Eligibility requirements

To be eligible for the study, participants must be 18 years of age or over, with current Major Depressive Disorder that has not improved with other treatments. Study participants would also need to be able to attend the Department of Psychiatry’s Clinical Research Facility, Royal Melbourne Hospitaltwice per week for the course of ketamine treatments.

The PREDDICT Study - Treatment of inflammation associated depression

The PREDDICT study investigates the addition of anti-inflammatory medication to usual antidepressant treatment for depression. The study is run by the Department of Psychiatry, with Professor Bernhard Baune as the Principal Investigator.

Antidepressant medication has therapeutic efficacy only in approximately one third of patients with depression. In addition, blood levels of inflammatory markers have been found to be mildly elevated in some people with depression. This study will investigate, by measuring inflammatory markers in the blood and correlating these with depression symptoms, the effects of a combined treatment of depression with anti-inflammatory medication and novel antidepressant medication.

Eligibility requirements

To be eligible for the study, participants must be aged between 18-65 years of age, with current Major Depressive Disorder. Study participants would attend the Department of Psychiatry’s Clinical Research Facility, Royal Melbourne Hospital.

The CERT-D Study - Treatment of psychosocial dysfunction in depression

The CERT-D study will test a new psychological intervention for depression targeting psychosocial dysfunction (e.g. workplace functioning, social relationships). The study is run by the Department of Psychiatry, with Professor Bernhard Baune as the Principal Investigator.

There is evidence that psychosocial dysfunction prevents recovery from depression. It follows that better psychosocial functioning should facilitate recovery and improve mental health in people with depression. The CERT-D treatment will involve completing an intervention designed to gradually improve cognitive, emotion processing, and social-cognitive  abilities, which are closely related to psychosocial functioning. The study will compare effects of personalised and standard treatment approaches.

Eligibility Requirements

To be eligible for the study, participants must be aged between 18-75 years of age with current major depressive disorder. Study participants would attend the Department of Psychiatry’s Clinical Research Facility, Royal Melbourne Hospital.

Cognitive Function and Mood Study (CoFaMS)

The Cognitive Function and Mood Study investigates the effects of depression and anxiety on psychosocial, workplace and day-to-day function also including cognitive function (for example concentration, memory, and attention). To do this, study participants complete questionnaires, a clinical interview, and a series of game-like computer based activities. The study is run by the Discipline of Psychiatry, with Professor Bernhard Baune as the Principal Investigator.

Eligibility requirements

To be eligible for the study, participants must be aged 18 years of age or over. Study participants can have current or past anxiety, depression, or bipolar disorder and participants are also welcome to be considered for the study if they are healthy people without a history of mental health problems. Study participants would attend the Department of Psychiatry’s Clinical Research Facility, Royal Melbourne Hospital.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Psychiatry


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