Optogenetics for precise neural stimulation

Summary The aim of this project is to develop the next generation of neural stimulation devices that use optical stimulation or combined optical/electrical stimulation in order to improve the precision of neural activation.

Project Details

The aim of this project is to develop the next generation of neural stimulation devices that use optical stimulation or combined optical/electrical stimulation in order to improve the precision of neural activation. The project will use cutting edge optogenetic techniques to express a light sensitive ion channel in neurons so that they can be activated with low-powered blue micro-LEDs. Electrophysiological recordings will be used to examine whether optical stimulation strategies can improve the spatial precision of neural activation. A significant advantage of improved precision of stimulation of the auditory nerve, for example, would be the ability to stimulate independent channels that would greatly enrich the auditory percept from a cochlear implant, such as the ability to perceive music.

General methods to be used in the project:
Electrophysiology, viral gene therapy, surgical device implantation, optical/electrical stimulation, optical modelling, cell culture, histology, immunohistochemistry, behavioural testing.

Suitable background of students:
This PhD project will suit a student who has first class honours or equivalent in any of the following disciplines: neuroscience, physiology, biomedical engineering, or similar degrees. Electrophysiology and cell culture skills are desirable.