Optical assessment of neuronal networks' function

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Florey Institute of Neuroscience & Mental Health
Primary Supervisor Email Number Webpage
Dr Timothy Karle tkarle@unimelb.edu.au
Co-supervisor Email Number Webpage
Prof Steven Petrou steven.petrou@florey.edu.au

Project Details

Visualising electrical neuronal activity with optics gives huge insight into physiological and disease processes.

Optical voltage and calcium imaging allows both spatial and temporal investigation of in-vitro neuronal culture dynamics.

When combined with optogenetics, neuron firing can be stimulated across the neuronal network. Studying the behaviour of networks formed from cells derived from genetic disease models and comparing these with healthy cells will drive understanding of genetic mutation in ion channels implicated in epilepsy.

This project will involve the culturing and transfection of mouse primary neuronal cultures and capturing fluorescent light with customised microscopes and fast CMOS camera.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Florey Institute of Neuroscience & Mental Health

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