Nuclear receptor co-regulators in heart disease and inflammation; new targets for fine-tuning receptor actions in health and disease

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Associate Professor Morag Young morag.young@baker.edu.au 03 8532 1111 Personal web page
Co-supervisor Email Number Webpage
Dr Kate Weeks kate.weeks@unimelb.edu.au Personal web page

Summary Nuclear receptors associate with co-regulatory proteins to modulate gene transcription: These co-regulators can have profound effects on receptor activity and may be targeted therapeutically for the treatment of a range of diseases. Our lab has identified several novel mineralocorticoid receptor (MR) co-regulators from the heart and kidney that control the overall activity of the MR and, importantly, its response to antagonists.

Project Details

Tissue culture approaches will be used to investigate how one or more novel coregulators modify MR function in heart and kidney cells under normal conditions, in stressed cells and in response to different hormone ligands of the MR. This project can be combined with a second project offered in this laboratory investigating other transcriptional partners for steroid hormone receptors, the HDAC family of transcriptional regulations. In this way, we hope to identify novel mechanisms of heart disease, determine the optimal way to treat patients and avoid the serious side effects of current treatments.
This project will include a suite of molecular biology techniques, cell culture, CoIP, western blotting, and RT PCR.


School Research Themes

Cardiometabolic



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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