Novel senescence markers predicting chemotherapy related toxicity and treatment outcome in older lung cancer patients

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
2
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Claire Maddison Claire.Maddison@mh.org.au 0393422635
Co-supervisor Email Number Webpage
Prof Andrea Maier andrea.maier@mh.org.au 0393422635 Personal web page

Project Details

The majority of cancers occur in patients over the age of 65 years. There is now widespread understanding that older patients are heterogeneous in terms of their physical, biological and social functioning, and that the biological age is predicting cancer treatment related outcome, such as toxicity and mortality. We hypothesis that biological markers characterising the hallmarks of ageing, especially cellular senescence and DNA damange, are linked to the treatment outcome.

The project is embedded in the ongoing, worldwide first RCT examining the utility of CGA and associated interventions in patients aged 65 years or older with a new diagnosis of non-small cell lung cancer. Patients are assessed at baseline and followed up at 3, 6 and 12 months. Novel senescence markers will be tested and related to the clinical phenotype and outcome of the patients. This research will eventually help predicting outcome of cancer patients and personalizing cancer treatment.

Prerequisite: interest in geriatric oncology, preferable lab skills, basic epidemiological/statistical skills, capacity to work in a multidisciplinary team, passion to unravel the ageing process.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine, Ageing



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

@AgeMelbourne

Research Node

Royal Melbourne Hospital

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