Neural modelling of epileptic dynamics

Summary This project aims to understand the links between the average single neuron behaviour with the behaviour of a network of neurons.  In particular, we would like to understand how the electrical behaviour becomes unstable, for example, when there is a transition to a seizure-like state from a normal or resting state. 

Project Details

This project aims to understand the links between the average single neuron behaviour with the behaviour of a network of neurons.  In particular, we would like to understand how the electrical behaviour becomes unstable, for example, when there is a transition to a seizure-like state from a normal or resting state.  We will use neurophysiology and neuroanatomy on multiple scales in combination with some mathematics to constrain the problem. This would involve some mathematical/statistical analysis and computational simulations that are strongly grounded in neuroscience.

Students with an interest in brain modelling and some background in either neuroscience/computer-science/engineering/physics/mathematics, particularly Matlab programming are encouraged to apply. Mathematical/ theoretical skills would be appreciated but are not as important as being interested/motivated/curious in a multi-disciplinary project.  The project can be tailored to suit the student’s background appropriately.