Nephrotoxicity screening using stem cell-derived proximal tubules

Research Opportunity
PhD students
Department / Centre
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Prof Melissa Little melissa.little@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Jessica Vanslambrouk jessica.vanslambrouk@mcri.edu.au

Summary Nephrotoxicity screening using stem cell-derived proximal tubules

Project Details

The kidney is a major target for drug-induced toxicity, however existing kidney epithelial cell lines in culture are very poor replicas of the proximal tubule in vivo. We have developed a method for generating complex multicellular 3D human kidney models in vitro using human pluripotent stem cells. This project will investigate how to use these as a platform for the screening of drug toxicity in vitro.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

PhD students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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