Monocytes in COVID-19: the great influencer of disease severity?

Research Opportunity
Masters by Research
Department / Centre
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Associate Professor Siddhartha Mahanty 83441972
Co-supervisor Email Number Webpage
Dr Louise Randall 83442181

Summary This project will examine how monocytes respond to SARS-CoV-2 infection and the role that they play in severe COVID-19.

Project Details

COVID-19 disease is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Although the global impact of infection is still evolving, it is apparent that COVID-19 presents as a spectrum of illness ranging from mild upper respiratory tract symptoms to a multisystem inflammatory syndrome. We do not know what causes this difference in disease severity amongst individuals. Severe COVID-19 is characterised by widespread tissue injury with inflammatory changes, suggesting an important role for innate and cellular immune responses in the pathogenesis of COVID-19.

Monocytes and macrophages are crucial for an effective early immune response and the monocyte response generated can greatly influence the resolution or progression of disease in a number of settings. We have an exciting project that aims to examine the monocyte response to antigens from SARS-CoV-2 and the common coronaviruses present in the community, such as NL63.

This project will involve monocyte isolation, in vitro cell culture, cytokine measurement assays and flow cytometry.

Faculty Research Themes

School Research Themes

Critical Care

Research Opportunities

Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre


Research Node

Royal Melbourne Hospital

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