Monocytes in COVID-19: the great influencer of disease severity?

Research Opportunity
Masters by Research, Master of Biomedical Science
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Associate Professor Siddhartha Mahanty smahanty@unimelb.edu.au 83441972
Co-supervisor Email Number Webpage
Dr Louise Randall louise.randall@unimelb.edu.au 83442181

Summary This project will examine how monocytes respond to SARS-CoV-2 infection and the role that they play in severe COVID-19.

Project Details

COVID-19 disease is caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Although the global impact of infection is still evolving, it is apparent that COVID-19 presents as a spectrum of illness ranging from mild upper respiratory tract symptoms to a multisystem inflammatory syndrome. We do not know what causes this difference in disease severity amongst individuals. Severe COVID-19 is characterised by widespread tissue injury with inflammatory changes, suggesting an important role for innate and cellular immune responses in the pathogenesis of COVID-19.

Monocytes and macrophages are crucial for an effective early immune response and the monocyte response generated can greatly influence the resolution or progression of disease in a number of settings. We have an exciting project that aims to examine the monocyte response to antigens from SARS-CoV-2 and the common coronaviruses present in the community, such as NL63.

This project will involve monocyte isolation, in vitro cell culture, cytokine measurement assays and flow cytometry.



Faculty Research Themes

Infection and Immunology

School Research Themes

Integrated Critical Care in Medicine



Research Opportunities

Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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