Monitoring for atypical femoral fracture (AFF) risk

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Medicine and Radiology
Royal Melbourne Hospital
Supervisor Email Number Webpage
Prof John Wark Personal web page
Dr Chris Yates Personal web page

Project Details

Evidence suggests that bisphosphonates and other antiresorptive therapy are associated with atypical fractures involving the femoral shaft. This adverse event may be related to treatment duration. As yet, no evidence-based protocol has been developed to monitor patients for this uncommon but serious adverse effect of therapy for osteoporosis, a very common and often disabling condition.

The aim of this project is to evaluate the utility of single-energy X-ray absorptiometry screening for femoral morphological changes predictive of AFF. Patients treated with antiresorptive medications for osteoporosis will be recruited for evaluation in the Bone Densitometry Unit when having clinical bone densitometry. A scoring system will be developed and applied to quantify AFF risk and will be compared with potential clinical predictors of risk.

Faculty Research Themes


School Research Themes

Neuroscience & Psychiatry, Musculoskeletal

Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

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Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Group / Unit / Centre

Bone and Mineral Research Group

Research Node

Royal Melbourne Hospital

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