Molecular signalling pathways controlling gene expression during chronic disease progression

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department / Centre
Medicine
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Adrian Achuthan aaa@unimelb.edu.au 83443298 Personal web page

Summary Inflammation is now known to be associated with many chronic diseases such as arthritis, cancer, Alzheimer’s disease, obesity, diabetes and heart diseases. This project aims to understand molecular signalling pathways controlling the expression of genes critical for the progression of such diseases. In this project you will explore in molecular terms how a particular inflammatory cell type (macrophage/dendritic cell) can adapt to provide a pro-inflammatory environment with consequences for persistence or otherwise of these significant diseases. More specifically you will investigate how transcription factors control the expression of pro-inflammatory and anti-inflammatory cytokines. Elucidation of these molecular pathways will lead to the development of novel therapies.

Project Details

Project description: Inflammation is now known to be associated with many chronic diseases such as arthritis, cancer, Alzheimer’s disease, obesity, diabetes and heart diseases. This project aims to understand molecular signalling pathways controlling the expression of genes critical for the progression of such diseases. In this project you will explore in molecular terms how a particular inflammatory cell type (macrophage/dendritic cell) can adapt to provide a pro-inflammatory environment with consequences for persistence or otherwise of these significant diseases. More specifically you will investigate how transcription factors control the expression of pro-inflammatory and anti-inflammatory cytokines. Elucidation of these molecular pathways will lead to the development of novel therapies.

Techniques: You will acquire a wide-range of skills in cell biology (primary human monocytes/macrophage culture, ELISA assays and flow cytometry), and biochemistry and molecular biology (Western blotting, Real‐Time PCR and siRNA‐mediated gene knock-down).



Faculty Research Themes

School Research Themes

Cancer in Medicine, Cardiometabolic , Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine

Research Node

Royal Melbourne Hospital

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