Molecular signalling pathways controlling gene expression during chronic disease progression

Research Opportunity
PhD, Masters by Research, Honours
Project Status
Medicine and Radiology
Royal Melbourne Hospital
Supervisor Email Number Webpage
Dr. Adrian Achuthan Personal web page

Project Details

Inflammation is now known to be associated with many chronic diseases such as cancer, Alzheimer’s disease, obesity/type II diabetes and heart disease.

This project aims to understand molecular signalling pathways controlling the expression of genes critical for the progression of such diseases. In this project you will explore in molecular terms how a particular inflammatory cell type (macrophage/dendritic cell) can adapt to provide a pro-inflammatory environment with consequences for persistence or otherwise of these significant diseases. More specifically you will investigate how transcription factors control the expression of pro-inflammatory and anti-inflammatory cytokines. Elucidation of these molecular pathways will lead to the development of novel therapies.

Faculty Research Themes

Infection and Immunology

School Research Themes


Research Opportunities

PhD, Masters by Research, Honours
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

View application process

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Node

Royal Melbourne Hospital

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