Molecular and biochemical analysis of novel disease variants in neurodevelopmental disorders

Summary The Synapse Biology & Cognition Laboratory is focused on understanding the critical role synaptic genes and proteins play in establishing and regulating the coordinated wiring and connectivity in the brain, that enables complex cognition and higher order processing in the healthy brain, and in mental disorders where these processes go awry. This project will use advanced protein binding and stability assays to measure the structural and functional impacts of novel synapse gene mutations identified in neurodevelopmental disorders including Autism Spectrum Disorder, Intellectual Disability and schizophrenia.

Project Details

The Synapse Biology & Cognition Laboratory is focused on understanding the critical role synaptic genes and proteins play in establishing and regulating the coordinated wiring and connectivity in the brain, that enables complex cognition and higher order processing in the healthy brain, and in mental disorders where these processes go awry. This project will use advanced protein binding and stability assays to measure the structural and functional impacts of novel synapse gene mutations identified in neurodevelopmental disorders including Autism Spectrum Disorder, Intellectual Disability and schizophrenia.