Modulation of toxic alpha synuclein in vivo
- Research Opportunity
- Honours, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
- Royal Children’s Hospital/Murdoch Childrens Research Institute
|Associate Professor Paul Lockhartfirstname.lastname@example.org||83416322||Personal web page|
|Doctor Sarah Stephensonemail@example.com||99366563|
Summary We are interested in understanding the mechanisms by which disease associated genes modulate alpha-synuclein within the brain. We hypothesise that genes that cause Parkinson's disease by loss of functional protein play a key role in eliminating toxic proteins such as alpha-synuclein from within the brain.
Parkinson's disease (PD) is a neurodegenerative disorder with a complex aetiology and progression. Mutations in the parkin gene are the most common cause of early onset-PD. Pathologically PD is characterised by loss of dopamine producing neurons and Lewy bodies composed of aggregated of alpha-synuclein. This has led to the hypothesis that reducing alpha-synuclein burden within cells may slow or halt disease progression. We have generated several novel Parkinson's disease mouse strains within our laboratory including knockout of causative disease genes parkin (with and without parkin's coregulated partner PACRG) and Rab39b. We are interested in understanding the mechanisms by which disease associated genes modulate alpha-synuclein within the brain. We hypothesise that genes that cause Parkinson's disease by loss of functional protein play a key role in eliminating toxic proteins such as alpha-synuclein from within the brain. Failure of their function results in the accumulation of toxic proteins and results in the development of PD. We have recently aged a number of unique cohorts that are dysregulated for multiple combinations of parkin/PACRG/Rab39B/alpha-synuclein in the laboratory. These will be characterised for markers of altered neuropathology, biochemistry and correlated with behaviour data already obtained.
Faculty Research Themes
School Research Themes
Honours, Master of Biomedical Science
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Research NodeRoyal Children’s Hospital/Murdoch Childrens Research Institute
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