Modelling diabetic-induced cardiomyopathy using human cardiac organoids

Research Opportunity
PhD, Master of Biomedical Science
Number of Master Places Available
1
Department
Surgery
Location
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
Dr Shiang (Max) Lim maxlim@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Jarmon Lees jlees@svi.edu.au

Summary Our lab has recently established a novel proprietary cardiac organoid model that contains heart cells, blood vessels and autonomic neurons completely derived from human induced pluripotent stem cells. This project aims to use this new pre-clinical human model to study the pathophysiology of diabetic heart disease and arrhythmias.

Project Details

For people with diabetes the risk of heart disease is 2-4 times higher than in adults without diabetes. In particular, people with diabetes are significantly more prone to cardiac arrhythmias, an irregular heartbeat that can be fatal. The cardiac autonomic nervous system (the nerves that innervate the heart) plays an important role in arrhythmias and contribute to heart failure. However, current pre-clinical human heart disease models completely lack this pivotal cell type. Our lab has recently established a novel proprietary cardiac organoid model that contains heart cells, blood vessels and autonomic neurons completely derived from human induced pluripotent stem cells. This project aims to use this new pre-clinical human model to study the pathophysiology of diabetic heart disease and arrhythmias.

The knowledge and skills involved in this project are suitable for students who are interested in stem cell biology, organoid research, cardiovascular disease and diabetes. A student working on this project will have the opportunity to learn various experimental skills, including; cell culture, protein and gene analysis, histology, electrophysiology and tissue engineering.


School Research Themes

Cardiometabolic



Research Opportunities

PhD, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Institute of Medical Research

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