Modelling cardiovascular diseases using human cardiac organoids

Research Opportunity
PhD students, Masters by Research
Department / Centre
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
Doctor Shiang Lim 03 9231 4020 Personal web page
Co-supervisor Email Number Webpage
Doctor Jarmon Lees Personal web page

Summary This project aims to construct a multicellular cardiac organoid model using cardiomyocytes and non-myocyte cell populations derived from human induced pluripotent stem cells to study heart disease.

Project Details

Heart disease continues to be the leading cause of death worldwide. Development of effective new drug candidates that are specific and effective for humans has been severely limited and a more detailed characterisation of human heart disease is urgently needed. However, this has been largely impeded by the limited access to viable human heart samples and by the cellular diversity of heart tissue. Our lab has recently established a novel proprietary cardiac organoid model that contains heart cells, blood vessels and autonomic neurons completely derived from human induced pluripotent stem cells. This project aims to use this new pre-clinical human model to study the pathophysiology of heart disease.

The knowledge and skills involved in this project are suitable for students who are interested in stem cell biology, organoid research, cardiovascular disease and diabetes. A student working on this project will have the opportunity to learn various experimental skills, including; cell culture, protein and gene analysis, histology, electrophysiology and tissue engineering.

School Research Themes


Research Opportunities

PhD students, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre


Research Node

St Vincent's Institute of Medical Research

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