Longitudinal predictors & characteristics of diet engagement in multiple sclerosis

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Steve Simpson, Jr. steve.simpson@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
A/Professor Tracey Weiland tweiland@unimelb.edu.au Personal web page

Project Details

Multiple sclerosis (MS) is a progressive, autoimmune, demyelinating condition of the central nervous system, manifesting in sensory, motor and/or cognitive dysfunction. Given its onset is typically in the prime years of life – often in the 20s – it has devastating impacts on the quality of life and independent living of the patients so affected.

Diet quality, and associated qualities like BMI and dyslipidaemia, have been implicated in MS onset and progression. Accordingly, a number of diets have been proposed which may improve clinical course in MS, including vegetarian, paleo, non-dairy, and other diets. People with MS, seeking to find some way to improve their disease, frequently attempt these diets but with varying degrees of adherence.

This project, making use of HOLISM longitudinal cohort study (n=1,401 at 2.5-yr follow-up, n=952 at 5-yr follow-up), will assess the prospective determinants, including demographic, clinical and lifestyle factors, of subsequent engagement with several prominent MS-specific diets reported at the 5-yr timepoint. Understanding the determinants of diet engagement will be of immense use in helping people stay on healthy diets, particularly in MS, as well as potentially having application in other health-related behaviours.

Analysis methods to be employed include linear regression, multilevel mixed-effects linear regression, log-binomial regression, and/or Poisson regression, including univariable and multivariable models, as well as potential inter-group assessment of interaction by sex, age, MS course, or others as appropriate.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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