Is the severity of illness associated with clinical malaria regulated by extracellular vesicles and their micro-RNA cargo?

Research Opportunity
Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Professor Siddhartha Mahanty smahanty@unimelb.edu.au 8344-1972 Personal web page
Co-supervisor Email Number Webpage
Professor Stephen Rogerson sroger@unimelb.edu.au 8344 3259

Project Details

Infection with Plasmodium falciparum (Pf) ranges in severity from asymptomatic parasitaemia to severe or fatal disease. Host- and parasite-derived factors are involved in determining severity of illness. Pf-infected red blood cells (iRBC) release small membrane particles, called extracellular vesicles (EV), into the circulation that directly interact with and influence host cells through the proteins and nucleic acids (RNA/DNA). EV are capable of transporting functional micro-RNA (miRNA). The goal of this project is to determine if extracellular vesicles in circulation and/or extracellular miRNA associated with vesicles contribute to the regulation of the clinical severity of falciparum malaria.



Faculty Research Themes

Infection and Immunology

School Research Themes

Integrated Critical Care in Medicine



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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