Is the severity of illness associated with clinical malaria regulated by extracellular vesicles and their micro-RNA cargo?
- Research Opportunity
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Professor Siddhartha Mahantyfirstname.lastname@example.org||8344-1972||Personal web page|
|Professor Stephen Rogersonemail@example.com||8344 3259|
Infection with Plasmodium falciparum (Pf) ranges in severity from asymptomatic parasitaemia to severe or fatal disease. Host- and parasite-derived factors are involved in determining severity of illness. Pf-infected red blood cells (iRBC) release small membrane particles, called extracellular vesicles (EV), into the circulation that directly interact with and influence host cells through the proteins and nucleic acids (RNA/DNA). EV are capable of transporting functional micro-RNA (miRNA). The goal of this project is to determine if extracellular vesicles in circulation and/or extracellular miRNA associated with vesicles contribute to the regulation of the clinical severity of falciparum malaria.
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