Investigating the role of signalling-specific mechanisms on tumour cell invasion

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Surgery
Location
Royal Melbourne Hospital
Group Leader Email Number Webpage
Dr Theo Mantmadiotis theom@unimelb.edu.au 85597065 Personal web page
Primary Supervisor Email Number Webpage
Dr Stanley Stylli sstylli@unimelb.edu.au 90355236 Personal web page

Project Details

This project will use molecular and cell-based techniques to investigate the role of key factors involved in regulating brain tumour growth, drug resistance and cancer stem cell biology. We recently reported a novel role of the cAMP pathway in triggering death in some brain cancer cell lines (1). The sensitivity or resistance of these cells to cAMP-induced death correlates with the MAPK pathway and CD44 expression. We have since developed a hypothesis that the transcription factors, Ets1 and Myb form a signalling-transcription network, cooperating with the cAMP, MAPK and PI3K pathways to enhance brain tumour cell malignancy and drug resistance.

Human and animal cell lines, patient-derived brain tumour cells and patient specimens will be used for experiments. PCR, IHC and other molecular techniques will be used to investigate how three signalling pathways act both individually and cooperate with to regulate malignant brain cancer tumour cell function, with a focus on tumour cell invasion.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Group / Unit / Centre

Research Node

Royal Melbourne Hospital

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