Investigating the role of OIP5-AS1 in cardiovascular diseases

Research Opportunity
Honours students
Number of Honour Places Available
1
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
A/Professor Brian Drew brian.drew@baker.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Aowen Zhuang aowen.zhuang@unimelb.edu.au Personal web page

Summary Students will have a strong focus on the characterisation of a novel gene and discovering the molecular mechanisms involved.

Project Details

Genes are a molecular instruction manual that makes each individual unique. Mutations in our genes are risk factors for the development of disease and often influence the severity of complex diseases such as cardiovascular disease. For example, a common known mutation of the BRCA gene can cause an increased risk of breast cancer.
Excitingly, recent advances in gene editing techniques have meant that we are now in an era where we can “fix” these errors in our genes, thanks largely to a new technology called CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). CRISPR has provided scientists with the equivalent of DNA editing software, which allows for site-specific editing of DNA that is akin to changing the individual letters in an incorrectly spelt word, rather than attempting to replace the whole word. Prior to this discovery, the resolution at which we are able to conduct gene-editing was previously not feasible.
This project will focus on the characterisation of a recently discovered gene (called OIP5-AS1) involved in cardiovascular disease with a strong emphasis on discovering the molecular mechanisms driving this phenotype. Deletion of OIP5-AS1 has profound effects on the pathogenesis of cardiovascular diseases, particularly heart failure. Discoveries made in this project will lead into the potential for therapeutic applications of targeting this novel gene using CRISPR-based technologies.

School Research Themes

Cardiometabolic



Research Opportunities

Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Group / Unit / Centre

Molecular Imaging and Theranostics Group Molecular Metabolism and Ageing Group

Research Node

Baker Heart and Diabetes Institute

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