Investigating the role of novel proteins and genes in gestational diabetes

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Obstetrics and Gynaecology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Associate Professor Martha Lappas mlappas@unimelb.edu.au 848 4370 Personal web page

Summary This project aims will use our unique biobank of human clinical samples to thoroughly characterise the role of novel genes/proteins in the pathophysiology of gestational diabetes.

Project Details

Gestational diabetes mellitus (GDM) complicates 15–20% of all pregnancies – a complication that reverberates into the future. The severe health and economic impacts of GDM can extend well beyond pregnancy and childbirth. The offspring of women with GDM are predisposed to an increased risk of metabolic and cardiovascular disease later in life. Despite the global health burden of gestational diabetes, the pathophysiology of the disease remains unclear, and therefore treatment options are limited. Our research has identified a number of genes and proteins that are dysregulated in gestational diabetes. Their role, however, in disease pathophysiology is not known.

This project aims will use our unique biobank of human clinical samples to thoroughly characterise the role of these genes/proteins in the pathophysiology of gestational diabetes. It is hoped that these biomolecules may be novel therapeutic target to reduce the incidence of GDM and its associated sequelae.

This project will use a range of laboratory methods including cell and tissue culture, molecular biology, enzyme immunoassays, and Western blot.



Faculty Research Themes

Child Health, Infection and Immunology

School Research Themes

Child Health in Medicine, Women's Health



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Obstetrics and Gynaecology

Research Group / Unit / Centre

Obstetrics, Nutrition and Endocrinology Group

Research Node

Royal Melbourne Hospital

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