Investigating the Rapamycin Effect on Induced-Palmitic osteocytes in Vitro
- Research Opportunity
- PhD students, Masters by Research
- Department / Centre
- Western Health
|Professor Gustavo Duquefirstname.lastname@example.org||Personal web page|
|Dr. Ahmed Al Seadiemail@example.com||Personal web page|
Summary The accumulation of fats in central regions of the body or peripherally can affect normal organ function, a condition referred to as lipotoxicity. This can also occur in bone and may affect bone health largely through the dysregulation of bone cell interactions and bone turnover
Within the bone marrow microenvironment, elevation in fatty acid levels may lead to an increase in osteoclast activity and a decrease in osteoblast number and function, thus contributing to age-related musculoskeletal diseases. In addition, Osteocytes is the orchestrator of bone remolding and decline in osteocyte autophagy is involved in senile osteoporosis. However, since rapamycin (RAP)-induced inhibition of target of rapamycin complex 1 (mTORC1) activates autophagy and prevents apoptosis, we hypothesized that RAP may preserve osteocytes viability and reduce PA-induced lipotoxicity.
School Research Themes
PhD students, Masters by Research
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Department / Centre
Research NodeWestern Health
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