Investigating the Rapamycin Effect on Induced-Palmitic osteocytes in Vitro

Summary The accumulation of fats in central regions of the body or peripherally can affect normal organ function, a condition referred to as lipotoxicity. This can also occur in bone and may affect bone health largely through the dysregulation of bone cell interactions and bone turnover

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Within the bone marrow microenvironment, elevation in fatty acid levels may lead to an increase in osteoclast activity and a decrease in osteoblast number and function, thus contributing to age-related musculoskeletal diseases. In addition, Osteocytes is the orchestrator of bone remolding and decline in osteocyte autophagy is involved in senile osteoporosis. However, since rapamycin (RAP)-induced inhibition of target of rapamycin complex 1 (mTORC1) activates autophagy and prevents apoptosis, we hypothesized that RAP may preserve osteocytes viability and reduce PA-induced lipotoxicity.