Investigating the Rapamycin Effect on Induced-Palmitic osteocytes in Vitro

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Western Health
Primary Supervisor Email Number Webpage
Professor Gustavo Duque gustavo.duque@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr. Ahmed Al Seadi ahmed.mohan@unimelb.edu.au Personal web page

Summary The accumulation of fats in central regions of the body or peripherally can affect normal organ function, a condition referred to as lipotoxicity. This can also occur in bone and may affect bone health largely through the dysregulation of bone cell interactions and bone turnover

Project Details

Within the bone marrow microenvironment, elevation in fatty acid levels may lead to an increase in osteoclast activity and a decrease in osteoblast number and function, thus contributing to age-related musculoskeletal diseases. In addition, Osteocytes is the orchestrator of bone remolding and decline in osteocyte autophagy is involved in senile osteoporosis. However, since rapamycin (RAP)-induced inhibition of target of rapamycin complex 1 (mTORC1) activates autophagy and prevents apoptosis, we hypothesized that RAP may preserve osteocytes viability and reduce PA-induced lipotoxicity.


School Research Themes

Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Western Health

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