Investigating the molecular basis of Parkinson’s Disease using novel mouse models

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Associate Professor Paul Lockhart paul.lockhart@mcri.edu.au 83416322 Personal web page
Co-supervisor Email Number Webpage
Dr Yujing Gao yujing.gao@mcri.edu.au 9936 6563

Summary The aim of this project is to characterise the function of RAB39B and investigate its role in the pathogenic mechanisms underlying Parkinson's disease. Studies will utilise newly developed and unique mouse models with mutations in RAB39B to perform preclinical studies to characterise disease processes and identify potential therapeutic targets.

Project Details

Parkinson's disease is a prevalent neurodegenerative disorder with largely unknown cause. However, recent advancements in genomic technologies have led to the identification of over 20 genes to be causative of around 10% of Parkinson's disease cases. The key neuropathological features of Parkinson's disease include a loss of dopamine producing neurons and the presence of alpha-synuclein containing protein aggregates in surviving neurons. We recently identified RAB39B as a novel gene for Parkinson's disease. RAB39B has a putative function in intracellular trafficking, and we hypothesise that it plays a role in the regulation of alpha-synuclein.   The aim of this project is to characterise the function of RAB39B and investigate its role in the pathogenic mechanisms underlying Parkinson's disease. Studies will utilise newly developed and unique mouse models with mutations in RAB39B to perform preclinical studies to characterise disease processes and identify potential therapeutic targets. The primary techniques to be utilised in this project will include mouse handling, behavioral testing and various molecular and cell biology assays.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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