Investigating the electrophysiology of neuronal network dynamics

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
St Vincent's Hospital
Primary Supervisor Email Number Webpage
Dr Andre Peterson peterson@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Prof Steve Petrou steven.petrou@florey.edu.au Personal web page
A/Prof Chris Reid christopher.reid@unimelb.edu.au Personal web page

Summary The aim of this project is to understand the relationship between brain structure and brain activity. Specifically, the aim is to uncover the relationship between the structure of in vitro and in vivo neuronal networks and their behaviour, specifically their synaptic connectivity and patterns of neuronal firing. Of particular interest is the pathological case of Epileptic networks that produce abnormal electrical activity.

Project Details

One of the current difficulties of treating neurological disease is that it is highly patient-specific, both diagnosis and treatment as everyone’s brain is wired differently.  The aim of this project is to understand the relationship between brain structure and brain activity.  Specifically, the aim is to uncover the relationship between the structure of in vitro and in vivo neuronal networks and their behaviour, specifically their synaptic connectivity and patterns of neuronal firing.  Of particular interest is the pathological case of Epileptic networks that produce abnormal electrical activity.  Although it is known how various channelopathies can give rise to abnormal neuronal firing, their effect on network dynamics is unclear as it is difficult to take into account the network connectivity.  This project uses and develops advanced electrophysiological methods to measure and quantify the relationship between synaptic connectivity and neuronal network activity.  Uncovering this relationship has the potential to lead to novel patient-specific treatments of neurological diseases such as Epilepsy that will drive the practice of  21st century Precision Medicine.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Hospital

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