Investigating the basis of antibiotic resistance in Mycoplasma genitalium

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Obstetrics and Gynaecology
Location
Royal Women’s Hospital
Primary Supervisor Email Number Webpage
Dr Gerald Murray gerald.murray@mcri.edu.au
Co-supervisor Email Number Webpage
Professor Suzanne Garland suzanne.garland@thewomens.org.au

Summary The project will use molecular methods including Sanger sequencing, quantitative PCR, and digital PCR, in combination with bacterial culture, to investigate the mutations that contribute to antibiotic resistance, and how these mutations arise.

Project Details

Antibiotic resistance is a substantial and growing problem. Our laboratory is investigating mechanisms of antibiotic resistance in Mycoplasma genitalium, a common sexually-transmitted bacterial pathogen. Infection with M. genitalium causes urethritis in men and can lead to reproductive complications for women.

M. genitalium has an unusual biology and highly reduced genome, making it susceptible to a small spectrum of antimicrobial reagents. Resistance to first line (macrolide) and second line (fluoroquinolone) treatments is high, and increasing. Dual resistance to both classes of antibiotic has increased, resulting in effectively “untreatable” infections.

The project will use molecular methods including Sanger sequencing, quantitative PCR, and digital PCR, in combination with bacterial culture, to investigate the mutations that contribute to antibiotic resistance, and how these mutations arise.

Developments in this area will contribute to our understanding of treatment failure. This will lead to the development of the next generation of diagnostic assays that report the presence of antibiotic resistance mutations, thereby allowing treatment to be tailored to the individual. The long term outcome will be improved antimicrobial stewardship.



Faculty Research Themes

Infection and Immunology

School Research Themes

Women's Health



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Obstetrics and Gynaecology

Research Node

Royal Women’s Hospital

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