Investigating the Anabolic Effect Drugs (Picolinic Acid) on Osteocytes in Vitro

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Western Health
Primary Supervisor Email Number Webpage
Professor Gustavo Duque gustavo.duque@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Ahmed Al Seadi ahmed.mohan@unimelb.edu.au Personal web page

Summary Wnt signalling proteins are small secreted proteins that are active in embryonic development, and tissue homeostasis. Wnt proteins bind to receptors on the cell surface, initiating a signalling cascade that leads to β-catenin activation of gene transcription.

Project Details

Wnt signalling proteins are small secreted proteins that are active in embryonic development, and tissue homeostasis. Wnt proteins bind to receptors on the cell surface, initiating a signalling cascade that leads to β-catenin activation of gene transcription. Our team has reported that Picolinic acid (PIC), an end product of the tryptophan degradation pathway, has an osteogenic effect on human mesenchymal stem cells (hMSCs). However, Osteocytes, >90% of the cells in bone, lie embedded within the mineralized matrix and coordinate osteoclast and osteoblast activity on bone surfaces. In addition, osteocytes as central target cells of the anabolic actions of canonical Wnt/β-catenin signalling in bone by mechanisms are still unclear. This project is aiming to explore the effect of PIC on human osteocytes in vitro.


School Research Themes

Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Western Health

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