Investigating cardiovascular disease in Friedreich's ataxia using human induced pluripotent stem cells

Research Opportunity
PhD, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Surgery
Location
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
Dr Shiang (Max) Lim maxlim@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Jarmon Lees jlees@svi.edu.au

Summary This project aims to generate patient-specific cardiovascular cells from induced pluripotent stem cells to establish novel human Friedreich's Ataxia disease models for disease modelling and drug discovery

Project Details

Friedreich’s ataxia (FRDA) is an autosomal recessive disease characterized by degeneration of neurons and heart disease. Reduced frataxin (FXN) protein due to GAA repeat expansions within the first intron of the FXN gene results in mitochondrial dysfunction and iron accumulation leading to increased oxidative stress and cell death in the nervous system and heart. There is currently no treatment to effectively cure, halt or even slow the progression of FRDA. This project aims to generate patient-specific cardiovascular cells from induced pluripotent stem cells to establish novel human FRDA disease models for disease modelling and drug discovery.

The knowledge and skills involved in this project are suitable for students who are interested in stem cell biology, cardiovascular disease, and mitochondrial biology. A student working on this project will have the opportunity to learn various experimental skills, including; cell culture, protein and gene analysis, histology and mitochondrial assays.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Cardiometabolic



Research Opportunities

PhD, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Institute of Medical Research

MDHS Research library
Explore by researcher, school, project or topic.