Investigating cardiovascular disease in Friedreich's ataxia using human induced pluripotent stem cells
- Research Opportunity
- PhD, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
- St Vincent's Institute of Medical Research
|Dr Shiang (Max) Limemail@example.com||Personal web page|
|Dr Jarmon Leesfirstname.lastname@example.org|
Summary This project aims to generate patient-specific cardiovascular cells from induced pluripotent stem cells to establish novel human Friedreich's Ataxia disease models for disease modelling and drug discovery
Friedreich’s ataxia (FRDA) is an autosomal recessive disease characterized by degeneration of neurons and heart disease. Reduced frataxin (FXN) protein due to GAA repeat expansions within the first intron of the FXN gene results in mitochondrial dysfunction and iron accumulation leading to increased oxidative stress and cell death in the nervous system and heart. There is currently no treatment to effectively cure, halt or even slow the progression of FRDA. This project aims to generate patient-specific cardiovascular cells from induced pluripotent stem cells to establish novel human FRDA disease models for disease modelling and drug discovery.
The knowledge and skills involved in this project are suitable for students who are interested in stem cell biology, cardiovascular disease, and mitochondrial biology. A student working on this project will have the opportunity to learn various experimental skills, including; cell culture, protein and gene analysis, histology and mitochondrial assays.
Faculty Research Themes
School Research Themes
PhD, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeSt Vincent's Institute of Medical Research
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