Inflammatory markers and cognitive function in schizophrenia

Research Opportunity
Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Psychiatry
Group Leader Email Number Webpage
Dr Vanessa Cropley vcropley@unimelb.edu.au +61 3 8344 1876 Personal web page
Primary Supervisor Email Number Webpage
Dr Tamsyn Van Rheenen tamsyn.van@unimelb.edu.au Personal web page

Project Details

Schizophrenia is a severe mental illness characterised by disturbances in perception, mood and cognitive (thinking) skills. Converging evidence has implicated immune system disruption in the disorder, however the impact of such alterations on cognition remains unclear. This project will examine the relationship between inflammatory markers in peripheral blood and cognitive performance, as well as potential mediators or moderators of this relationship, in individuals with schizophrenia and healthy controls. Cytokines assessed include TNF-a, IL1b, IL2, IL4, IL5, IL6, IL7, IL8, IL10, IL12, IL13 and IFN-G. Cognitive ability has been assessed across several domains including working memory, associative memory, behavioural flexibility and social cognition. Mediators of the association between inflammation and cognition might include brain volume whereas potential moderators could include childhood adversity or specific genetic variants of immune-related genes. The student will be responsible for conducting a literature review of the area, the development of the proposal and generation of study hypotheses, as well as data processing and statistical analyses.

Supervisors: Dr Vanessa Cropley, Dr Tamsyn Van Rheenen, Ms Cassandra Wannan, Ms Liliana Laskaris



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Psychiatry

Research Group / Unit / Centre


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