Inflammatory markers and cognitive function in schizophrenia
- Research Opportunity
- Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
|Tamsyn Van Rheenenfirstname.lastname@example.org||Personal web page|
|Vanessa Cropleyemail@example.com||+61 3 8344 1876||Personal web page|
Schizophrenia is a severe mental illness characterised by disturbances in perception, mood and cognitive (thinking) skills. Converging evidence has implicated immune system disruption in the disorder, however the impact of such alterations on cognition remains unclear. This project will examine the relationship between inflammatory markers in peripheral blood and cognitive performance, as well as potential mediators or moderators of this relationship, in individuals with schizophrenia and healthy controls. Cytokines assessed include TNF-a, IL1b, IL2, IL4, IL5, IL6, IL7, IL8, IL10, IL12, IL13 and IFN-G. Cognitive ability has been assessed across several domains including working memory, associative memory, behavioural flexibility and social cognition. Mediators of the association between inflammation and cognition might include brain volume whereas potential moderators could include childhood adversity or specific genetic variants of immune-related genes. The student will be responsible for conducting a literature review of the area, the development of the proposal and generation of study hypotheses, as well as data processing and statistical analyses.
Supervisors: Dr Vanessa Cropley, Dr Tamsyn Van Rheenen, Ms Cassandra Wannan, Ms Liliana Laskaris
Faculty Research Themes
School Research Themes
Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
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