Inflammatory cytokines involved in obesity and osteoarthritis

Research Opportunity
PhD students, Masters by Research, Honours students, Post Doctor Researchers
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Kevin Lee mingchinl@unimelb.edu.au 0433343647 Personal web page
Co-supervisor Email Number Webpage
Prof. John Hamilton jahami@unimelb.edu.au +61383445480 Personal web page

Summary Osteoarthritis (OA) is a most common form of arthritis and is associated with many risk factors, for example, obesity. Inflammatory cytokines have been implicated in facilitating OA progression. This project will use animal models of OA to identify a novel potential therapeutic target(s) for treating OA symptoms (i.e. pain)

Project Details

Osteoarthritis (OA) affects 7% of the global population, more than 500 million people worldwide, with women disproportionately affected. The prevalence and the severity of OA is increasing due to increasing population obesity (a risk factor). Current therapeutic approaches, for example, opioids, mainly manage symptoms (e.g. pain), albeit rather ineffectively, and do not alleviate the degenerative burden of disease (i.e. progression into late stage OA). Improving analgesic management of OA pain with potential to prevent the progression of this disease is thus of critical importance and will directly improve the lives of OA patients worldwide.


Inflammatory cytokines have been implicated in the pathogenesis of OA, particularly in the context of obesity-exacerbated OA. The project will involve a diverse range of experimental approaches, including animal models of OA, pain assessment, histological analysis, and gene and protein analysis, to explore whether a particular cytokine(s) is important for the development of OA and obesity.



Faculty Research Themes

Infection and Immunology

School Research Themes

Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students, Post Doctor Researchers
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine

Research Node

Royal Melbourne Hospital

MDHS Research library
Explore by researcher, school, project or topic.