Immunological responses following pneumococcal conjugate vaccination

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Associate Professor Paul Licciardi paul.licciardi@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Doctor Dan Pellicci dan.pellicci@mcri.edu.au Personal web page
Professor Kim Mulholland kim.mulholland@lshtm.ac.uk

Summary This project will measure cellular immune responses following reduced dose PCV schedules in Vietnam using flow cytometry. Results from this study will facilitate our understanding of PCV-induced immunity and will contribute to the global evidence on reduced dose PCV evaluation.

Project Details

Pneumococcal diseases such as pneumonia, meningitis and sepsis are the biggest killers of children under 5 years of age worldwide, mostly in low- and middle-income countries (LMICs). There are two currently licensed pneumococcal conjugate vaccines (PCVs), PCV10 (Synflorix®, GlaxoSmithKline) and PCV13 (Prevnar-13®, Pfizer). As these are expensive vaccines, there has been an emphasis on PCV schedules with reduced numbers of doses that rely more on herd immunity, mediated by reduction in carriage, rather than individual protection. However, the immunological determinants of long-term protection against pneumococcal carriage are poorly understood. In Vietnam, we are currently undertaking a randomised trial of reduced dose schedules of the two licensed PCVs, and have developed approaches to measure B-cell memory (Bmem), follicular T helper cells (Tfh), Th17 cells and agglutinating antibodies to comprehensively examine the immune response following PCV. This project will measure cellular immune responses following reduced dose PCV schedules in Vietnam using flow cytometry. Results from this study will facilitate our understanding of PCV-induced immunity and will contribute to the global evidence on reduced dose PCV evaluation.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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