Identifying circadian clock and mineralocorticoid receptor (MR) interactions in heart disease

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Associate Professor Morag Young morag.young@baker.edu.au 03 8532 1111 Personal web page

Summary The mineralocorticoid receptor (MR) is best known for the physiological control of blood pressure acting in the kidney under the control of the hormone aldosterone. The MR is also found in many other cell types including the heart and inflammatory cells where another hormone cortisol, not aldosterone, activates the receptor. Until recently the role of cortisol-MR signalling was largely unknown.

Project Details

Our recent studies identified reciprocal regulation of the molecular clock and the MR is and showed this interaction is important in heart disease. However, we do not understand the molecular mechanisms of the MR and molecular clock interaction and how these change across the circadian day. The outcomes of these studies will help us to understand how modern environmental circadian disruptors (e.g. jetlag) interfere with the body’s normal response to steroid hormones. Understanding how the molecular circadian clock and the MR interact will support development of chronotherapeutic approaches for cardiovascular disease therapies.
Techniques for this project will include cell culture, western blotting, FACS, immunocytochemistry, RT-PCR and molecular screening techniques.
This project will also involve bioinformatic analysis of large databases and potentially preclinical animal models.


School Research Themes

Cardiometabolic , Women's Health, Infectious Diseases and Immunity



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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