Identification of novel vaccine targets that induce protective immunity against malaria

Research Opportunity
Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Burnet Institute
Group Leader Email Number Webpage
Gaoqian Feng gaoqian.feng@burnet.edu.au 85062383 Personal web page
Primary Supervisor Email Number Webpage
James Beeson arzum.cubuk@burnet.edu.au Personal web page

Project Details

Development of a highly effective vaccine against malaria is greatly needed for global elimination of malaria. However, currently this is hindered because of a limited knowledge of the mechanisms and specific targets of immunity to malaria. We have used a wide range of approaches to identify mechanisms involving antibody interactions with Fc-receptors and complement that may be crucial for effective immunity against malaria.

This project will use our recent developed technologies and approaches to identify targets and epitopes that induce functional antibodies. The project will focus on key antigens expressed by malaria during its initial invasion stage. The project will involve the use of multiple cellular, molecular, and antibody assays to identify potential targets that could be included in vaccines. Studies will also investigate the optimal combinations of antibody targets that induce functional immunity in a synergistic manner

This project is suitable for a student with a keen interest in humoral and cellular immunology and vaccine development. The student will acquire unique skills in performing immunoassays including ELISA, monocyte/neutrophil isolation, flow-cytometry and immune-fluorescent staining, phagocytosis assays, as well as standard techniques in cell culture and analysing data from population studies.



Faculty Research Themes

Infection and Immunology

School Research Themes

Child Health in Medicine, Women's Health



Research Opportunities

Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Burnet Institute

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