Identification of blood markers of delayed concussion in children
- Research Opportunity
- Number of Honour Places Available
- Royal Children’s Hospital/Murdoch Childrens Research Institute
|Associate Professor Vera Ignjatovicfirstname.lastname@example.org||99366520||Personal web page|
|Prof Vicki Andersonemail@example.com||Personal web page|
|Professor Franz Bablfirstname.lastname@example.org|
Summary This project aims to utilize the complex proteomics SWATH-MS dataset to identify plasma proteins associated with delayed clinical outcomes post-concussion in children. Validation using ELISA and/or MS approach will be required.
Traumatic brain injury (TBI) is defined as "an alteration in brain function, or other evidence of brain pathology, caused by an external force". Mild traumatic brain injury (mTBI) is one of the most common forms of TBI and accounts for one out of every 220 paediatric patients admitted to the emergency department within the United States, totalling approximately 144,000 patients per year on a national level and 18% of all paediatric head injury patients. An audit of children who attended the Royal Children's Hospital (RCH), Melbourne, Australia in 2004 for a head injury found that 90% of the patients were classified as a mTBI. While most children improve within one week following a mTBI, there is growing consensus that symptoms can persist for up to one month in approximately 30% of patients, with approximately 40% of individuals remaining symptomatic 2 weeks post-injury. This differs significantly from that of adults, a population which sees most individuals recover within a 2 week period. These prolonged symptoms, which may include headaches, dizziness, difficulties concentrating, irritability, cognitive/emotional impairments, and behavioural difficulties carry the potential to develop into significant cognitive, academic and emotional-behavioural difficulties if left unchecked. The last decade has seen a progressive shift to blood proteome analysis as a means of assisting the determination of clinical diagnosis, prognosis and outcome in the setting of concussion. To date, very few studies have investigated the differential plasma protein expression following paediatric mTBI, and specifically the association of blood proteins with delayed clinical outcomes post-concussion in children. We have recently utilized the SWATH-MS analysis to assess changes in expression of up to 400 plasma proteins. This allowed for an unbiased discovery of proteins not yet implicated in concussion research. This project aims to utilize the complex proteomics SWATH-MS dataset to identify plasma proteins associated with delayed clinical outcomes post-concussion in children. Validation using ELISA and/or MS approach will be required.
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Research NodeRoyal Children’s Hospital/Murdoch Childrens Research Institute
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