Identification of additional markers of ferroptosis with mass spectrometry

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Professor Peter Meikle peter.meikle@baker.edu.au 85321770 Personal web page
Co-supervisor Email Number Webpage
Dr Kevin Huynh kevin.huynh@baker.edu.au Personal web page

Summary Interrogate the role of ether lipids (with antioxidant properties) in ferroptosis and their potential to mediate and regulate the process in various biological settings.

Project Details

Ferroptosis is a specific form of cell death mediated by the accumulation of oxidised lipids. Several studies have highlighted this important process in relation to multiple diseases including cancer and neurodegeneration. While the biological mechanisms of lipid oxidation have been demonstrated to be a key factor, measurement of these lipid species is complicated in an in vivo setting. This project aims to identify and develop new ways of measuring molecules related to ferroptosis, using a combination of controlled in cell culture experiments and mass spectrometry assays.  The assays developed will then be used to interrogate the role of ether lipids (with antioxidant properties) in ferroptosis and their potential to mediate and regulate the process in various biological settings.

Type of student: Honours, Masters or PhD. Particularly students that are technology/computation oriented with interest in cell culture.


School Research Themes

Cardiometabolic



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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