How does the brain remove the excess number of neurons during development and aging
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science, Post Doctor Research
- Number of Honour Places Available
- Number of Master Places Available
- Medicine and Radiology
- Florey Institute of Neuroscience & Mental Health
|Dr. Ben Gufirstname.lastname@example.org||+61390356317||Personal web page|
|Prof. James Wileyemail@example.com||+61383446386||Personal web page|
Summary This project will focus on the recognition mechanisms for apoptotic cells to be recognized and captured by phagocytes.
Many more neurons are produced during development than are present in the adult brain. Also many neurons are lost during aging, however the process of innate phagocytosis, which removes unwanted and superfluous neurons is poorly defined. The unwanted neurones enter apoptosis but subsequent clearance of these dying cells is important for our body to avoid autoimmunity or inflammation in the brain. Apoptotic cells express unique markers which enable them to be recognized and engulfed by phagocytes. The knowledge of these unique markers is limited at present to certain cell membrane lipids, e.g. phosphatidylserine. Recent novel finding from our laboratory suggests that a unique protein epitope is expressed early in apoptosis and this is recognized by P2X7 receptors on phagocytes. This project will examine how apoptotic cells are recognized and cleared by phagocytes both in health and in disease. This result will have relevance to many neurological diseases as well as early neurodevelopment.
Techniques involved are cell culture, immunoprecipitation, western blotting, flow cytometry, peptide screen, molecular biology and mass spectrometry.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science, Post Doctor Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeFlorey Institute of Neuroscience & Mental Health
MDHS Research library
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