How does bone matrix composition determine bone strength?

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
Medicine and Radiology
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
A/Prof Natalie Sims Personal web page

Project Details

Although bone strength is partially determined by the amount of bone in the skeleton, the material composition of bone also influences its strength.

We have developed a new method using the Australian Synchrotron Infra-Red beamline to assess bone composition in cortical bone, which allows us to study the process by which bone matrix becomes mineralized and how this determines bone strength. This project will examine a range of bone samples from different genetically altered mouse models, and under different physiological stresses by synchrotron-based Fourier-Transform Infra-red Microspectroscopy to provide new insights into how bone composition controls bone strength.

This project will use histology and histomorphometry, micro-computed tomography, synchrotron-based Fourier-Transform Infra-red Microspectroscopy, and spectral analysis techniques.

This project is conducted in St Vincent’s Institute of Medical Research, Bone Cell Biology and Disease Unit.

School Research Themes


Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Group / Unit / Centre

Bone cell biology and disease unit

Research Node

St Vincent's Institute of Medical Research

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