How do antibodies against Plasmodium falciparum gametocytes induce transmission blocking immunity?

Research Opportunity
Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Associate Professor Siddhartha Mahanty smahanty@unimelb.edu.au 03-8344-1972
Co-supervisor Email Number Webpage
Professor Stephen Rogerson sroger@unimelb.edu.au 8344 3259

Project Details

Immunity against sexual stage, that underpin transmission-blocking vaccines (TBV), directed at parasite molecules expressed in the gametocyte through to ookinete stages are not well-understood. Antibodies (Ab) directed against these molecules are likely be crucial for transmission blocking immunity (TBI). We aim to characterise sexual stage targets of Ab from individuals with Plasmodium falciparum(Pf) infections, the cause of the most severe form of malaria.  We will use biochemical and immunological techniques to identify and functionally characterise anti-gametocyte antibodies that mediate TBI using in sera obtained from malaria-infected individuals to better understand the properties of Abs that confer TBI.



Faculty Research Themes

Infection and Immunology

School Research Themes



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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