How do antibodies against Plasmodium falciparum gametocytes induce transmission blocking immunity?
- Research Opportunity
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Associate Professor Siddhartha Mahantyfirstname.lastname@example.org||03-8344-1972|
|Professor Stephen Rogersonemail@example.com||8344 3259|
Immunity against sexual stage, that underpin transmission-blocking vaccines (TBV), directed at parasite molecules expressed in the gametocyte through to ookinete stages are not well-understood. Antibodies (Ab) directed against these molecules are likely be crucial for transmission blocking immunity (TBI). We aim to characterise sexual stage targets of Ab from individuals with Plasmodium falciparum(Pf) infections, the cause of the most severe form of malaria. We will use biochemical and immunological techniques to identify and functionally characterise anti-gametocyte antibodies that mediate TBI using in sera obtained from malaria-infected individuals to better understand the properties of Abs that confer TBI.
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