How do Anti-Epileptic Drugs Work?

Project Details

Despite many years of use and research, it is still not clear how even some of the oldest forms of antiepileptic drugs (AED’s) work. What is known is generally based on the effects of these compounds on single neurons, rather than examining how activity of the whole inter-connected neural network of the mammalian CNS is modulated. This project involves studying the effects of AED’s at several levels of organization of the CNS – single channel (voltage-gated sodium, potassium and calcium channels), single neuron, principal neuron/interneuron dynamics, as well as glial cell effects.

Patch clamp techniques are used for recording dissociated neuron and neurons in the intact brain slice, and these observations will be extended with high-speed calcium imaging with conventional microscopy as well as multiphoton techniques. This projects affords excellent opportunities for skill development in electrophysiology, pharmacology advanced microscopy and computational neuroscience as well as conference presentation and publication opportunities. Check out https://ndl-lab.org/home