High Dose Vitamin D and Post-Stroke Outcomes: A Randomized Controlled Trial

Research Opportunity
PhD, Masters by Research
Medicine and Radiology
Western Health
Primary Supervisor Email Number Webpage
Associate Professor Tissa Wijeratne twi@unimelb.edu.au Personal web page

Project Details

Levels of serum 25-hydroxyvitamin D (25(OH)D) have been shown to serve as a predictor of cardiovascular disease risk, and an independent predictor of functional outcome post-acute ischemic stroke. While the prevalence of 25 (OH)D deficiency is high in patients with acute ischemic stroke, provision of vitamin D supplementation as a therapeutic agent has not clearly been established in this patient population. The current study aims to investigate the effects of vitamin D supplementation on functional outcomes. It is hypothesized that high dose vitamin D supplementation could improve post-stroke outcomes in acute ischemic stroke patients with low 25 (OH)D levels. 100 acute ischemic stroke patients with low 25 (OH)D levels will be recruited and be randomly assigned to one of two groups. One group will receive a loading dosing of 50000 units of vitamin D followed by 1000 units daily for three months. The other group will receive 1000 units of vitamin daily, without a loading dose. Stroke outcomes (death, disability using modified Rankin Score, NIHSS) will be compared across the two groups.

Faculty Research Themes


School Research Themes

Neuroscience & Psychiatry, Cardiometabolic

Research Opportunities

PhD, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Node

Western Health

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