Gut epithelial stem cell function: the influence of enteric neurons

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Doctor Lincon Stamp lstamp@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Doctor Marlene Hao hao.m@unimelb.edu.au Personal web page
Associate Professor Sebastian King Sebastian.King@rch.org.au

Summary This study, which includes novel co-culturing of organoids and enteric neurospheres, will identify signalling pathways and cellular mechanisms by which nerves influence the epithelia during homeostasis and ageing. This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells.

Project Details

This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. The role of epithelial stem cell-nerve communication, and the signalling pathways mediating it, are currently poorly understood.    This study, which includes novel co-culturing of organoids and enteric neurospheres, will identify signalling pathways and cellular mechanisms by which nerves influence the epithelia during homeostasis and ageing.    The outcome of the project will be a better understanding of the biology of the body's most highly proliferative, long-lived stem cells; intestinal epithelial stem cells.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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