GM-CSF-mediated molecular signalling pathways contributing to inflammation

Research Opportunity
PhD, Masters by Research, Master of Biomedical Science
Number of Honour Places Available
2
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Adrian Achuthan aaa@unimelb.edu.au 83443298 Personal web page

Project Details

GM-CSF is a pro-survival factor for monocytes, macrophages and granulocytes, and can activate them for enhanced inflammatory mediator levels. Depletion of GM-CSF has been show to suppress arthritis in animal models. Clinical trials in rheumatoid arthritis (RA) targeting GM-CSF or its receptor have reported success in Phase II, although its mode of action remains unknown. Recent data from our laboratory suggested that a GM-CSF regulated chemokine CCL17 could be critical for the pro-inflammatory actions of GM-CSF. This project will investigate whether GM-CSF-mediated CCL17 production contributes to the inflammatory cytokine production in RA synovium and synovial macrophages/dendritic cells.



Faculty Research Themes

Infection and Immunology

School Research Themes

Musculoskeletal



Research Opportunities

PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

MDHS Research library
Explore by researcher, school, project or topic.