GM-CSF-mediated molecular signalling pathways contributing to inflammation
- Research Opportunity
- PhD, Masters by Research, Master of Biomedical Science
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr Adrian Achuthanemail@example.com||83443298||Personal web page|
GM-CSF is a pro-survival factor for monocytes, macrophages and granulocytes, and can activate them for enhanced inflammatory mediator levels. Depletion of GM-CSF has been show to suppress arthritis in animal models. Clinical trials in rheumatoid arthritis (RA) targeting GM-CSF or its receptor have reported success in Phase II, although its mode of action remains unknown. Recent data from our laboratory suggested that a GM-CSF regulated chemokine CCL17 could be critical for the pro-inflammatory actions of GM-CSF. This project will investigate whether GM-CSF-mediated CCL17 production contributes to the inflammatory cytokine production in RA synovium and synovial macrophages/dendritic cells.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeRoyal Melbourne Hospital
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