Genotype and Phenotype Characterisation Human Circulating Osteo-Progenitor (COP) Cells

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Western Health
Primary Supervisor Email Number Webpage
Professor Gustavo Duque gustavo.duque@unimelb.edu.au Personal web page

Summary COP (circulating osteogenic progenitor cells) is a term referring to circulating bone marrow-derived progenitor stem cells, which are able to participate in bone formation such as bone marrow-derived mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC). The origin and function of COP cells remain unknown. However, some studies have reported that COP cells are recruited from bone marrow and perivascular niche to fracture sites in order to enhance healing.

Project Details

COP cell levels have been reported to be associated with postmenopausal-osteoporotic state and heterotopic calcification or bone formation states. A low bone mineral density (BMD) in postmenopausal women seems to have an inverse relationship with COP cell levels.Low percentage of COP cells has been also associated with disability and frailty in older persons. However, the genetic and biological phenotype of COP cells has not been fully characterised. This project will use genetic and molecular techniques to fully characterise COP cells from young and older individuals. Results of this project will allow us to determine whether COP cells could be a useful approach as a biomarker and/or treatment to musculoskeletal diseases and frailty.


School Research Themes

Ageing



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Western Health

MDHS Research library
Explore by researcher, school, project or topic.