Genomic and Immune cell profiling of sebaceous skin lesions for optimising identification of patients with Lynch syndrome
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Clinical Pathology
|A/Prof Daniel Buchananfirstname.lastname@example.org||0385597004||Personal web page|
|Prof Ingrid Winshipemail@example.com||Personal web page|
Sebaceous neoplasms describe rare skin tumours involving the sebaceous glands that include sebaceous adenomas, sebaceous carcinomas and sebaceomas (collectively referred to as sebaceous neoplasia). Muir-Torre syndrome (MTS) is a phenotypic variant of Lynch syndrome, where carriers of germline mutations in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, PMS2), develop sebaceous neoplasia and are at risk of developing internal (non-cuaneous) malignancies, predominantly colorectal cancer. Therefore, the presence of sebaceous neoplasia may be an early warning sign for Lynch syndrome, for which there are effective risk management plans for cancer prevention if a carrier is identified. We have assembled an internationally unique resource of sebaceous neoplasia tissue from Lynch and non-Lynch individuals. The aim of this project is to profile the somatic mutation and immune cell landscape in sebaceous neoplasia from Lynch syndrome carriers and from non-carriers. This project will develop expertise in genomics, histology, bioinformatic and statistical analysis. The outcomes of this project will have significant international impact through development of genomic and immune landscape of sebaceous neoplasia which may result in improved triaging of patients who present with sebaceous neoplasia for the identification of Lynch syndrome. A stipend for this project is available to the selected student.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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