Gamma oscillations in genetic mouse models of schizophrenia

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Nigel Jones nigel.jones@monash.edu 99030862 Personal web page
Matt Hudson matt.hudson@monash.edu 99030862

Project Details

Current treatments for schizophrenia remain inadequate, particularly when it comes to treating cognitive dysfunction, which is increasingly being considered a crucial aspect of the disorder. Recent developments in schizophrenia research propose high frequency neuronal oscillations in the gamma frequency band (30-80Hz) are abnormal in the disorder. Considering gamma oscillatory activity has been shown to be closely associated with sensory and cognitive processes, it has been suggested that these gamma oscillatory abnormalities may be closely linked to cognitive impairment in schizophrenia. The neuronal mechanisms underlying gamma oscillatory activity are unclear, however, several neuronal subtypes may be involved. For this project, we will investigate the involvement of specific cell types in the regulation of gamma oscillatory activity through the use of genetically modified mice. Specifically, genetically modified mice in which specific neuronal cell types are altered will undergo surgical implantation of electrodes to allow for the recording of oscillatory activity in several brain regions. Experiments will then be conducted to record oscillatory activity during cognitive behavioural tasks. Through this approach, we hope to enhance understanding of the neuronal mechanisms underlying gamma oscillatory activity and to determine whether alterations in gamma oscillatory activity are linked to cognitive ability.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

MDHS Research library
Explore by researcher, school, project or topic.