Gamma oscillations in genetic mouse models of schizophrenia
- Research Opportunity
- PhD, Masters by Research, Honours
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr Matt Hudsonfirstname.lastname@example.org||99030862|
|A/Prof Nigel Jonesemail@example.com||99030862||Personal web page|
Summary For this project, we will investigate the involvement of specific cell types in the regulation of gamma oscillatory activity through the use of genetically modified mice.
Current treatments for schizophrenia remain inadequate, particularly when it comes to treating cognitive dysfunction, which is increasingly being considered a crucial aspect of the disorder. Recent developments in schizophrenia research propose high frequency neuronal oscillations in the gamma frequency band (30-80Hz) are abnormal in the disorder. Considering gamma oscillatory activity has been shown to be closely associated with sensory and cognitive processes, it has been suggested that these gamma oscillatory abnormalities may be closely linked to cognitive impairment in schizophrenia. The neuronal mechanisms underlying gamma oscillatory activity are unclear, however, several neuronal subtypes may be involved. For this project, we will investigate the involvement of specific cell types in the regulation of gamma oscillatory activity through the use of genetically modified mice. Specifically, genetically modified mice in which specific neuronal cell types are altered will undergo surgical implantation of electrodes to allow for the recording of oscillatory activity in several brain regions. Experiments will then be conducted to record oscillatory activity during cognitive behavioural tasks. Through this approach, we hope to enhance understanding of the neuronal mechanisms underlying gamma oscillatory activity and to determine whether alterations in gamma oscillatory activity are linked to cognitive ability.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeRoyal Melbourne Hospital
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