Functional role of VEZT over expression in endometrium

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Obstetrics and Gynaecology
Location
Royal Women’s Hospital
Primary Supervisor Email Number Webpage
Dr Jacqueline Donoghue jacqueline.donoghue@unimelb.edu.au Personal web page

Summary VEZT is the first protein coding gene that can be directly linked to increased susceptibility for endometriosis. At a population level, SNPs associated with an increased risk for endometriosis are also associated with increased VEZT expression in the endometrium. To date, it is unclear what functional role VEZT has in the development or progression of endometriosis. To generate new knowledge about VEZT and endometriosis, we have developed a novel mouse model that conditionally over-expresses VEZT ubiquitously including the reproductive system. Our primary aim is to characterise the impact increased expression VEZT has on fertility as well as endometrial lesion formation. This project will include working with an animal model of endometriosis, protein and molecular studies.

Project Details


School Research Themes

Women's Health



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Obstetrics and Gynaecology

Research Node

Royal Women’s Hospital

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