Exploring how a high salt diet promotes bone destruction through immune cell activation

Research Opportunity
PhD students, Masters by Research, Honours students
Department / Centre
Baker Department of Cardiometabolic Health
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Prof Andrew Murphy andrew.murphy@baker.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr. Sam Lee Mankitsam.lee@baker.edu.au

Summary Diets rich in salt have been linked to bone pathologies. This has generally been attributed to mineral exchange, causing weaker bones. However, our group hypothesized that this process is biologically driven. We have made initial discoveries to show that specific immune cells are produced and activated by a high salt diet that is linked with bone destruction. This project will focus on the novel mechanisms contributing to this discovery. Specifically, this project will determine how the immune cells interact and activate osteoclasts within the bone and will explore where these immune cells are first activated. We anticipate these findings being important across several age groups and will explore ways to offset these detrimental effects of high salt intake. The student will be exposed to a world class research environment and cutting-edge techniques, with excellent supervision. Techniques will include flow cytometry, sectioning of tissues (including bones), immunofluorescence, micro CT and multiphoton microscopy.

Project Details

Faculty Research Themes

Infection and Immunology

School Research Themes

Cardiometabolic , Musculoskeletal

Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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