Exploration of novel approaches to anti-cancer treatment: manipulation of mutant p53

Research Opportunity
PhD, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Supervisor Email Number Webpage
Sue Haupt sue.haupt@petermac.org +61385596477
Ygal Haupt ygal.haupt@petermac.org +613 8559 7102

Project Details

P53 is the most mutated gene in human cancer, affecting about half the cases of cancer, and involved in every cancer type. We have recently identified novel regulators of mutant p53 using sophisticated loss of function whole genome high content screen. In this project the candidate will study a key novel regulator derived from this screen to explore the interplay with mutant p53, and to define novel target for anti-cancer drugs. The student will explore the efficacy of manipulating these regulators as a novel approach to treating cancer cells bearing mutant p53 (majority of human cancers). The project will involve work with cancer cell lines, transgenic mouse models, and human samples. In addition the project will expose students to a variety of molecular, cellular biochemical techniques, as well as to genomic and bioinformatics analyses.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology


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